{"id":64250,"date":"2022-06-08T08:05:11","date_gmt":"2022-06-08T14:05:11","guid":{"rendered":"https:\/\/www.uchealth.org\/today\/?p=64250"},"modified":"2022-06-24T08:52:24","modified_gmt":"2022-06-24T14:52:24","slug":"biosticker-detects-fever-and-more-among-at-risk-cancer-patients","status":"publish","type":"post","link":"https:\/\/www.uchealth.org\/today\/biosticker-detects-fever-and-more-among-at-risk-cancer-patients\/","title":{"rendered":"BioSticker detects fever \u2013 and more \u2013 among at-risk cancer patients"},"content":{"rendered":"
<\/div>
\"Logan
Logan and James Byrne<\/figcaption><\/figure>\n

James Byrne hadn\u2019t been out of the hospital for long when a call came in after midnight. He answered to the voice of a triage nurse asking him how he was feeling. He was pretty tired, actually, having been through radiation treatment and chemotherapy designed to eradicate his acute myeloid leukemia<\/a> and then an allogeneic bone marrow transplant<\/a> (his son Logan had been the key donor; his cells were augmented with donated umbilical-cord stem cells). That and having been asleep until his cell phone rang. But otherwise, just fine, he said.<\/p>\n

Good to hear, the nurse said \u2013 because Byrne\u2019s body temperature had just jumped to 98.9 degrees. While that\u2019s just a shade higher than the standard 98.6 degrees, his temperature had been hanging around 97 degrees, so what would otherwise seem normal might instead have been an indication of a brewing infection. Given that his immune system had been wiped out and was just starting to rebuild itself, an infection would pose a serious risk to the 45-year-old resident of Albuquerque, N.M. This was, fortunately, a red flag that could be safely lowered again.<\/p>\n

Byrne would have had a hard time taking his own temperature while sound asleep. A three-inch by one-inch, U.S. Food and Drug Administration-approved medical device called a BioSticker had done that and much more.<\/p>\n

Biosticker as an early warning system<\/strong><\/h2>\n

Before Byrne left UCHealth University of Colorado Hospital<\/a> on the Anschutz Medical Campus<\/a>, the UCHealth and University of Colorado School of Medicine advanced practice practitioner leading the study, Glen Peterson<\/a>, had asked him if he might be interested in joining one of two cancer-related clinical trials using the remote-monitoring gadget developed by Golden-based BioIntelliSense<\/a>. This one would involve sticking the BioSticker to his upper chest and largely forgetting about it for 30 days. The BioSticker would collect a steady stream of his vital signs \u2013 body temperature, respiratory rate, resting heart rate, skin temperature, gait, body position and more \u2013 and transmit it to UCHealth providers via a wireless hub and Reimagine Care<\/a>, a startup focused on home cancer care. The goal would be to spot emerging health problems before Byrne himself did.<\/p>\n

It\u2019s not the first work UCHealth has done with BioIntelliSense. Their collaborations through the UCHealth CARE Innovation Center<\/a> have most notably involved remote monitoring of high-risk COVID-19 patients<\/a>. But Dr. Richard Zane<\/a>, UCHealth\u2019s chief innovation officer and chair of the CU School of Medicine\u2019s Department of Emergency Medicine, says the technology could apply to a wide range of health conditions.<\/p>\n

\"The
The BioIntelliSense BioSticker. Photo courtesy of BioIntelliSense.<\/figcaption><\/figure>\n

\u201cIt\u2019s about bringing remote patient monitoring to wherever the patient is, understanding how to ingest key vital signs, and building predictive and prescriptive algorithms on top of those data so that we can intervene before we otherwise would have,\u201d Zane said.<\/p>\n

BioSticker establishes a baseline to judge abnormalities<\/strong><\/h2>\n

Technologies such as BioIntelliSense\u2019s BioSticker and the recently announced BioButton<\/a> \u2013 an even-smaller stick-on medical device that captures much of the same data as its predecessor \u2013 have the potential to supplant \u201can outdated system\u201d of discharged patients self-reporting their own health status, as Dr. Clay Smith, director of the UCHealth Blood Disorders and Cell Therapies Center<\/a> and associate chief of the CU School of medicine\u2019s Division of Hematology, put it.<\/p>\n

\"\"
Dr. Glen Peterson<\/figcaption><\/figure>\n

Byrne\u2019s example of having a lower-than-usual body temperature is a case in point. The typical approach of having people take their temperature a couple of times a day and report fevers to caregivers assumes 98.6 as the \u201cnormal\u201d temperature. But it can vary from person to person, as it did with Byrne; it can be lowered by medications; it can go up on a hot day or even when wearing a hat. A long-term monitoring device such as the BioSticker, which captures and transmits 1,440 measurements every 24 hours, day and night, can establish baselines from which to judge abnormalities.<\/p>\n

\u201cWe see people who are quite ill who have a \u2018normal\u2019 temperature and those with a higher temperature who are fine,\u201d Smith said.<\/p>\n

Help with more than fevers<\/strong><\/h2>\n

The second UCHealth-BioIntelliSense study also relates to body temperature. That study, which Peterson also leads, involves cancer patients whose chemotherapy has left them with low numbers of white blood cells called neutrophils that help fight infections. These patients are susceptible to febrile neutropenia<\/a> \u2013 a fever caused by an infection that exploits the weakened immune system. Febrile neutropenia cases account for about 5%<\/a> of all adult cancer-related hospitalizations in the United States, with an average stay of more than eight days.<\/p>\n

\"Dr.
Dr. Clay Smith<\/figcaption><\/figure>\n

The sooner one can spot a fever or other signs of nascent illness, the faster the patient can get treatment.<\/p>\n

\u201cWe know that, the longer you wait from the time infection starts, the worse the outcomes,\u201d Smith said. \u201cIt\u2019s important to detect it as soon as possible, figure out what type of infection it is, and start antibiotics.\u201d<\/p>\n

Fevers are only the beginning, Smith says. He sees technologies such as the BioSticker feeding diverse readings into artificial-intelligence-powered systems capable of synthesizing body temperature, heart rate, respiratory rate, movement characteristics, and other factors to \u201cdetect a whole range of problems and alert health care providers to nip health problems in the bud.\u201d<\/p>\n

Zane says BioIntelliSense\u2019s work with UCHealth is already moving in that direction. They\u2019ve identified patterns in the data that seem to predict fevers while a patient\u2019s temperature is still normal. Such insight could one day let providers prescribe antibiotic pills for patients at home to beat back infections before they\u2019re serious, thereby avoiding hospitalization for intravenous antibiotics.<\/p>\n

James Byrne\u2019s BioSticker has triggered a few calls over the month he has worn it, he says. One involved a 3:30 a.m. call from a nurse practitioner triggered by a change in his breathing patterns \u2013 and indeed, he had been coughing for much of the night. The nurse had him check his pulse oxygen level; it was normal.<\/p>\n

Another had to do with a leap in his heart rate. He happened to have been walking around quite a bit at the time, he says, and he isn\u2019t in the best shape of his life for obvious reasons. The triage nurse explained why she was calling and asked, \u201cYou doing alright?\u201d<\/p>\n

\u201cI\u2019m doing just fine,\u201d he answered.<\/p>\n

But it was nice to get that call.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

James Byrne hadn\u2019t been out of the hospital for long when a call came in after midnight. He answered to the voice of a triage nurse asking him how he was feeling. He was pretty tired, actually, having been through radiation treatment and chemotherapy designed to eradicate his acute myeloid leukemia and then an allogeneic […]<\/p>\n","protected":false},"author":23,"featured_media":64551,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[5],"tags":[28,3273],"class_list":["post-64250","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-innovative-care","tag-cancer-care-oncology","tag-innovative-medical-technologies"],"acf":[],"yoast_head":"\nBioSticker detects more than just fever in cancer patients - 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